A global catalog of whole-genome diversity from 233 primate species
Resource type
Journal article
Creator (person)
Kuderna, Lukas F K
Gao, Hong
Janiak, Mareike C
Kuhlwilm, Martin
Orkin, Joseph D
Bataillon, Thomas
Manu, Shivakumara
Valenzuela, Alejandro
Bergman, Juraj
Rousselle, Marjolaine
Silva, Felipe Ennes
Agueda, Lidia
Blanc, Julie
Gut, Marta
de Vries, Dorien
Goodhead, Ian
Harris, R Alan
Raveendran, Muthuswamy
Jensen, Axel
Chuma, Idrissa S
Horvath, Julie E
Hvilsom, Christina
Juan, David
Frandsen, Peter
Schraiber, Joshua G
de Melo, Fabiano R
Bertuol, Fabràcio
Byrne, Hazel
Sampaio, Iracilda
Farias, Izeni
Valsecchi, Joà£o
Messias, Malu
da Silva, Maria N F
Trivedi, Mihir
Rossi, Rogerio
Hrbek, Tomas
Andriaholinirina, Nicole
Rabarivola, Clément J
Zaramody, Alphonse
Jolly, Clifford J
Phillips-Conroy, Jane
Wilkerson, Gregory
Abee, Christian
Simmons, Joe H
Fernandez-Duque, Eduardo
Kanthaswamy, Sree
Shiferaw, Fekadu
Wu, Dongdong
Zhou, Long
Shao, Yong
Zhang, Guojie
Keyyu, Julius D
Knauf, Sascha
Le, Minh D
Lizano, Esther
Merker, Stefan
Navarro, Arcadi
Nadler, Tilo
Khor, Chiea Chuen
Lee, Jessica
Tan, Patrick
Lim, Weng Khong
Kitchener, Andrew C
Zinner, Dietmar
Gut, Ivo
Melin, Amanda D
Guschanski, Katerina
Schierup, Mikkel Heide
Beck, Robin M D
Umapathy, Govindhaswamy
Roos, Christian
Boubli, Jean P
Rogers, Jeffrey
Farh, Kyle Kai-How
Marques Bonet, Tomas
Date published
June 2, 2023
Abstract
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-standing questions in evolutionary and conservation biology and is urgent given severe threats these species are facing. Here, we present high-coverage whole-genome data from 233 primate species representing 86% of genera and all 16 families. This dataset was used, together with fossil calibration, to create a nuclear DNA phylogeny and to reassess evolutionary divergence times among primate clades. We found within-species genetic diversity across families and geographic regions to be associated with climate and sociality, but not with extinction risk. Furthermore, mutation rates differ across species, potentially influenced by effective population sizes. Lastly, we identified extensive recurrence of missense mutations previously thought to be human specific. This study will open a wide range of research avenues for future primate genomic research.
Journal title
Science
Volume
380
Issue
6648
Publisher
American Association for the Advancement of Science (AAAS)
ISSN
0036-8075
eISSN
1095-9203
Date accepted
February 6, 2023
Official URL
Rights statement
In Copyright