Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

Gharibi, Hassan; Chernobrovkin, Alexey L; Eriksson, Gunilla; Saei, Amir Ata; Timmons, Zena; Kitchener, Andrew C; Kalthoff, Daniela C; Lidén, Kerstin; Makarov, Alexander A; Zubarev, Roman A

Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

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Journal article

Creator (person)

Gharibi, Hassan

ORCID

Chernobrovkin, Alexey L

ORCID

Eriksson, Gunilla

Saei, Amir Ata

ORCID

Timmons, Zena

Kitchener, Andrew C

ORCID

Kalthoff, Daniela C

Lidén, Kerstin

Makarov, Alexander A

ORCID

Zubarev, Roman A

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Date published

February 16, 2022

Abstract

Analyzing the Î´2H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher Î´2H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”.

Funder

Funder name	Awards
Vetenskapsrà¥det
Svenska Là¤karesà¤llskapet	SLS-961262
Ministry of Science and Higher Education of the Russian Federation	075-15-2020-899